{"id":59722,"date":"2022-06-09T14:11:43","date_gmt":"2022-06-09T12:11:43","guid":{"rendered":"https:\/\/www.donat.com\/?p=59722"},"modified":"2022-06-09T14:11:44","modified_gmt":"2022-06-09T12:11:44","slug":"utjecaj-mikrobiote-na-opce-zdravstveno-stanje","status":"publish","type":"post","link":"https:\/\/www.donat.com\/bs\/utjecaj-mikrobiote-na-opce-zdravstveno-stanje\/","title":{"rendered":"Utjecaj mikrobiote na op\u0107e zdravstveno stanje"},"content":{"rendered":"\n

Istra\u017eivanja provedena posljednjih nekoliko godina dokazala su koliko je va\u017ena mikrobna zajednica za zdravstveno stanje \u010dovjeka.[1,2,3,4] Na kvalitativni i kvantitativni sastav crijevne mikrobiote utje\u010de puno \u010dimbenika, me\u0111u ostalim prehrambene navike i na\u010din \u017eivota. Smetnje u radu crijevne mikroflore slabe reakciju imunosnog sustava, omogu\u0107uju razvoj metaboli\u010dkih poreme\u0107aja i uzrokuju alergijske reakcije.[3,4] Suvremenim dijagnosti\u010dkim metodama mo\u017ee se u potpunosti otkriti rad gena brojnih predstavnika crijevne mikroflore. Istra\u017eivanjima poku\u0161avamo otkriti povezanost izme\u0111u smetnji u radu u slu\u010daju promjena mikrobiote i razli\u010ditih humanih bolesti. Profil crijevne zajednice kod svake je osobe druga\u010diji, ali je u 75 % \u010dine bakterije Verrucomicrobia, Firmicutes, Bacteroides, Fusibacteria, Proteobacteria i Actinobacteria,[5] a definira je genom konkretnog \u010dovjeka.[6] Ljudsko zdravlje i op\u0107u homeostazu omogu\u0107uju neki najva\u017eniji predstavnici grampozitivne anaerobne mikroflore \u2013 laktobacili i bifidobakterije. Ako ih ima dovoljno, u\u010dinkovito sprje\u010davaju naseljavanje strane mikroflore u crijeva.[7] Crijevni mikrobiom utje\u010de i na rad osi mikrobiota \u2013 crijeva \u2013 mozak, i tako da poti\u010de rad nespecifi\u010dne imunosti te endokrinog, \u017eiv\u010danog i imunosnog sustava.[8]<\/p>\n\n\n\n

Slika 1 Rad normalne crijevne mikroflore[11]<\/strong><\/strong><\/p>\n\n\n

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\u0160tevilne endokrine in psihovegetativne motnje so med drugim povezane s pomanjkanjem in motnjo absorpcije magnezija v organizmu.[9] V Mnogobrojne endokrine i psihovegetativne smetnje povezane su, me\u0111u ostalim, s nedostatkom i smetnjama u apsorpciji magnezija u organizmu.[9] U istra\u017eivanju, koje smo proveli od 2013. do 2016. godine, tijekom promatranja instrumentima te laboratorijskim i klini\u010dkim pra\u0107enjem djece i tinejd\u017eera (134 osoba od 10 do 18 godina) utvrdili smo da je nedostatak magnezija povezan s funkcionalnim zatvorom.[10] Smetnje energetskih, neurokemijskih i metaboli\u010dkih procesa u stanicama sredi\u0161njeg i vegetativnog \u017eiv\u010danog sustava uzrokuju smetnje u psihi, emocijama i procesima prilago\u0111avanja, a zatim uzrokuju i funkcionalne smetnje u obliku zatvora. U spomenutoj kategoriji bolesnika konzumiranje ljekovite mineralne vode Donat u ukupnoj dnevnoj koli\u010dini od 300 do 500 ml, i to triput na dan 20 minuta prije jela tijekom 18 dana stabiliziralo je rad gastrointestinalnog trakta, pobolj\u0161alo mogu\u0107nosti rada sredi\u0161njeg i vegetativnog \u017eiv\u010danog sustava te oja\u010dalo sposobnosti prilagodbe organizma, a sve to je stabiliziralo homeostazu i dinami\u010dku ravnote\u017eu osi mozak \u2013 crijevo.<\/p>\n\n\n

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Popis literature<\/h3>\n\n\n\n
  1. Borre Y.E., Moloney R.D., Clarke G., Dinan T.G., Cryan J.F. The impact of microbiota on brain and behavior: mechanisms and therapeutic potential \/\/ Adv. Exper. Med. Biol., 2014, I. 817, P. 373\u2013403.<\/li>
  2. Young V.B. The intestinal microbiota in health and disease \/\/ Opin. Gastroenterol., 2012, I. 28, P. 63\u201369.<\/li>
  3. Tilg H., Kaser A. Gut microbiome, obesity, and metabolic dysfunction \/\/ J. Clin. Invest., 2011, I. 121, P. 2126\u20132132.<\/li>
  4. Kelsen J.R., Wu G.D. The gut microbiota, environment and diseases of modern society \/\/ Gut Microbes, 2012, I. 3, P. 374\u2013382.<\/li>
  5. Arumugam M., Raes J., Pelletier E., Le Paslier D., et al. Enterotypes of the human gut microbiome \/\/ Nature, 2011, I. 473, P. 174\u2013180.<\/li>
  6. Turnbaugh P.J., Hamady M., Yatsunenko T., Cantarel B.L., Duncan A., Ley R.E., Sogin M.L., Jones W.J., Roe B.A., Affourtit J.P., Egholm M., Henrissat B., Heath A.C., Knight R., Gordon J.I. A core gut microbiome in obese and lean twins \/\/ Nature, 2009, I. 457, P. 480\u2013484.<\/li>
  7. Vandenplas Y., Huys G., Daube G. Probiotics: an update \/\/ J. Pediatr. (Rio J.), 2015, I. 91, P. 6\u201321.<\/li>
  8. Stilling R.M., Dinan T.G., Cryan J.F. Microbes do have a significant impact on epigenetic regulation in the host\u2019s gut epithelium and immune system, microbial genes, brain and behaviour-epigenetic regulation of the gut-brain axis \/\/ Genes Brain Behav., 2014, I. 13, P. 69\u201386.<\/li>
  9. \u0421\u0435\u043c\u0438\u0433\u043e\u043b\u043e\u0432\u0441\u043a\u0438\u0439 \u041d.\u042e. \u0414\u0435\u0444\u0438\u0446\u0438\u0442 \u043c\u0430\u0433\u043d\u0438\u044f \u043a\u0430\u043a \u043e\u0431\u0449\u0435\u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u044f \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0430. \u0422\u0440\u0443\u0434\u043d\u044b\u0439 \u043f\u0430\u0446\u0438\u0435\u043d\u0442. 2008;7: 31\u201335.<\/li>
  10. \u0417\u0430\u0445\u0430\u0440\u043e\u0432\u0430 \u0418.\u041d. \u0420\u043e\u043b\u044c \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430 \u043c\u0430\u0433\u043d\u0438\u044f \u0432 \u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0437\u0430\u043f\u043e\u0440\u0430 \u0443 \u0434\u0435\u0442\u0435\u0439 \u0438 \u043f\u043e\u0434\u0440\u043e\u0441\u0442\u043a\u043e\u0432 \/ \u0418.\u041d. \u0417\u0430\u0445\u0430\u0440\u043e\u0432\u0430, \u0422.\u041c. \u0422\u0432\u043e\u0440\u043e\u0433\u043e\u0432\u0430, \u041b.\u041b. \u0421\u0442\u0435\u043f\u0443\u0440\u0438\u043d\u0430, \u041b.\u0418. \u0415\u043b\u0435\u0437\u043e\u0432\u0430 \/\/ \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0441\u043e\u0432\u0435\u0442. \u2013 2019. \u2013 \u211611. \u2013 \u0421. 16\u201324.<\/li>
  11. Romanchuk N.P., Romanchuk P.I. (2019). Neurophysiology and neurorehabilitation of cognitive disorders and disorders \/\/ Bulletin of Science and Practice, I. 5(11), P. 176\u2013196. (https:\/\/doi.org\/10.33619\/2414-2948\/48\/19 (in Russian)).<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    Istra\u017eivanja provedena posljednjih nekoliko godina dokazala su koliko je va\u017ena mikrobna zajednica za zdravstveno stanje \u010dovjeka.[1,2,3,4] Na kvalitativni i kvantitativni sastav crijevne mikrobiote utje\u010de puno \u010dimbenika, me\u0111u ostalim prehrambene navike i na\u010din \u017eivota. Smetnje u radu crijevne mikroflore slabe reakciju imunosnog sustava, omogu\u0107uju razvoj metaboli\u010dkih poreme\u0107aja i uzrokuju alergijske reakcije.[3,4] Suvremenim dijagnosti\u010dkim metodama mo\u017ee se …<\/a><\/p>\n","protected":false},"author":5,"featured_media":95905,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[149],"tags":[],"class_list":["post-59722","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-bs"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/posts\/59722","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/comments?post=59722"}],"version-history":[{"count":1,"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/posts\/59722\/revisions"}],"predecessor-version":[{"id":95912,"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/posts\/59722\/revisions\/95912"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/media\/95905"}],"wp:attachment":[{"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/media?parent=59722"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/categories?post=59722"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.donat.com\/bs\/wp-json\/wp\/v2\/tags?post=59722"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}