{"id":59258,"date":"2022-06-09T14:01:49","date_gmt":"2022-06-09T12:01:49","guid":{"rendered":"https:\/\/www.donat.com\/?p=59258"},"modified":"2022-06-09T14:01:50","modified_gmt":"2022-06-09T12:01:50","slug":"pravilna-probava-i-crijevna-mikrobiota","status":"publish","type":"post","link":"https:\/\/www.donat.com\/hr\/pravilna-probava-i-crijevna-mikrobiota\/","title":{"rendered":"Pravilna probava i crijevna mikrobiota"},"content":{"rendered":"\n

Gastrointestinalni trakt omogu\u0107uje me\u0111usobno djelovanje ljudskog organizma i vanjskog okru\u017eenja. Pritom vrlo va\u017enu ulogu igra barijera crijevne sluznice, a na njezin rad utje\u010du smetnje probavnih procesa, apsorpcije i metabolizma. Crijevna barijera uskla\u0111uje fiziolo\u0161ke procese koji omogu\u0107uju normalnu homeostazu. U lumenu crijeva djeluju razli\u010diti \u010dimbenici okru\u017eenja koji utje\u010du na mikrobiotu.[1] Lokacija i gusto\u0107a mikroorganizama u probavnom traktu razli\u010diti su tako u uzdu\u017enom (od usne \u0161upljine do sfinktera) kao i u popre\u010dnom smjeru (od epitelija do lumena). Na razli\u010dit sastav i gusto\u0107u mikroba utje\u010du pH, koncentracija \u017eu\u010di, dostupnost hranjivih tvari, uskla\u0111en rad imunosnog sustava i dr.[2] Bakterije su najgu\u0161\u0107e naseljene u debelom crijevu, i to od 1011 do 1012 bakterija po gramu, tj. 60 % cjelokupne mase stolice.[3] Voda se izlu\u010duje po \u010ditavom gastrointestinalnom traktu, od dvanaesnika do donjeg dijela debelog crijeva. Epitelij mora biti hidriran kako bi pravilno radio.<\/p>\n\n\n

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Ako sastav mikrobiote gastrointestinalnog trakta nije pravilan, signalni sustav osi mikrobiota \u2013 crijeva \u2013 mozak mo\u017ee prestati pravilno raditi, \u010dime se mijenja peristaltika crijeva.[4,5] Na peristaltiku crijeva mogu djelovati i krajnji proizvodi bakterijske fermentacije. Utvr\u0111eno je da na crijevnu peristaltiku tako\u0111er utje\u010de imunosni sustav jer se pojavljuju novi dokazi o upalnoj reakciji kod nekih bolesnika sa zatvorom. Zato je iznimno va\u017eno osigurati pravilnu probavu kod bolesnika sa smetnjama crijevnog mikrobioma te time utjecati na kvalitetu i koli\u010dinu sastava crijeva.<\/p>\n\n\n\n

U istra\u017eivanjima (Bothe G., Coh A., Auinger A., 2015, Indejkina L. H., 2018) izvje\u0161tava se o tome da ljekovita mineralna voda Donat utje\u010de na rad gastrointestinalnog trakta.[6,7] U istra\u017eivanjima je uz statisti\u010dku zna\u010dajnost dokazano da konzumiranje 200 ml ljekovite mineralne vode tri puta na dan u razdoblju od tri tjedna skra\u0107uje vrijeme prijenosa sadr\u017eaja crijeva i normalizira u\u010destalost defekacije. Donat djeluje kao osmotski laksativ i omogu\u0107uje besprijekoran rad \u017eu\u010dnog mjehura te time poti\u010de izlu\u010divanje \u017eu\u010dne kiseline i rad gu\u0161tera\u010de te utje\u010de na nastanak enzima.<\/p>\n\n\n\n

Konzumiranje ljekovite mineralne vode Donat (Slovenija, Roga\u0161ka Slatina) stoga se mo\u017ee preporu\u010diti u slu\u010daju smetnji u redovitom pra\u017enjenju crijeva jer mo\u017ee omogu\u0107iti udoban opstanak mikrobne zajednice u crijevima.<\/p>\n\n\n

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Popis literature<\/h3>\n\n\n\n
  1. Zhu H., Hart C.A., Sales D., Roberts N.B. \u0411\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0435 \u0443\u0431\u0438\u0439\u0441\u0442\u0432\u043e \u0432 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e\u043c \u0441\u043e\u043a\u0435 \u2013 \u0432\u043b\u0438\u044f\u043d\u0438\u0435 \u0440\u041d \u0438 \u043f\u0435\u043f\u0441\u0438\u043d\u0430 \u043d\u0430 Escherichia coli \u0438 Helicobacter pylori. J. Med. \u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b., 2006, I. 55, P. 1265\u20131270.<\/li>
  2. Tropini C., Earle K.A., Huang K.C., Sonnenburg J.L. \u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043c \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430: \u043f\u043e\u0434\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u0438 \u043a \u0444\u0443\u043d\u043a\u0446\u0438\u0438. Cell Host Microbe, 2017, I. 21, P. 433\u2013442.<\/li>
  3. Sekirov I.,Russell S.L., Antunes L.C., Finlay B.B. \u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u0442\u0430 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430 \u0432 \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u0435 \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438. \u0424\u0438\u0437\u0438\u043e\u043b. REV., 2010, I. 90, P. 859\u2013904.<\/li>
  4. Kennedy P.J., Clarke G., Quigley E.M., Groeger J.A., Dinan T.G., Cryan J.F. Gut memories: towards a cognitive neurobiology of irritable bowel syndrome. Neurosci Biobehav Rev. 2012, I. 36, P. 310\u2013340.<\/li>
  5. Carabotti M., Scirocco A., Maselli M.A., Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol., 2015, I. 28, P. 203\u2013209.<\/li>
  6. Bothe G., Coh A., Auinger A. Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: a double-blind, randomized, placebocontrolled study. Eur J Nutr 2015. (https:\/\/link.springer.com\/article\/10.1007\/s00394-015-1094-8)<\/li>
  7. \u0418\u043d\u0434\u0435\u0439\u043a\u0438\u043d\u0430 \u041b.\u0425. \u041e\u0446\u0435\u043d\u043a\u0430 \u0432\u043b\u0438\u044f\u043d\u0438\u044f \u043b\u0435\u0447\u0435\u0431\u043d\u043e\u0439 \u043c\u0438\u043d\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0439 \u0432\u043e\u0434\u044b \u0414\u043e\u043d\u0430\u0442 \u041c\u0430\u0433\u043d\u0438\u044f (Donat) \u043d\u0430 \u043c\u043e\u0442\u043e\u0440\u043d\u043e-\u044d\u0432\u0430\u043a\u0443\u0430\u0442\u043e\u0440\u043d\u0443\u044e \u0444\u0443\u043d\u043a\u0446\u0438\u044e \u0442\u043e\u043b\u0441\u0442\u043e\u0439 \u043a\u0438\u0448\u043a\u0438 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u043c\u0438 \u0437\u0430\u043f\u043e\u0440\u0430\u043c\u0438 \/ \u041b.\u0425. \u0418\u043d\u0434\u0435\u0439\u043a\u0438\u043d\u0430, \u0415.\u0421. \u0421\u043e\u043a\u043e\u043b\u043e\u0432\u0430, \u041d.\u0413. \u0421\u0430\u043c\u0441\u043e\u043d\u043e\u0432\u0430, \u0410.\u0418. \u041f\u0430\u0440\u0444\u0435\u043d\u043e\u0432 \/\/ \u0414\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. \u2013 \u21161. \u2013 2018. \u2013 \u0421. 59-60. (https:\/\/doi.org\/10.17116\/dokgastro20187155-110)<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    Gastrointestinalni trakt omogu\u0107uje me\u0111usobno djelovanje ljudskog organizma i vanjskog okru\u017eenja. Pritom vrlo va\u017enu ulogu igra barijera crijevne sluznice, a na njezin rad utje\u010du smetnje probavnih procesa, apsorpcije i metabolizma. Crijevna barijera uskla\u0111uje fiziolo\u0161ke procese koji omogu\u0107uju normalnu homeostazu. U lumenu crijeva djeluju razli\u010diti \u010dimbenici okru\u017eenja koji utje\u010du na mikrobiotu.[1] Lokacija i gusto\u0107a mikroorganizama u probavnom …<\/a><\/p>\n","protected":false},"author":5,"featured_media":95870,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[150],"tags":[],"class_list":["post-59258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-strucni-clanci"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/posts\/59258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/comments?post=59258"}],"version-history":[{"count":5,"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/posts\/59258\/revisions"}],"predecessor-version":[{"id":95877,"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/posts\/59258\/revisions\/95877"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/media\/95870"}],"wp:attachment":[{"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/media?parent=59258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/categories?post=59258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.donat.com\/hr\/wp-json\/wp\/v2\/tags?post=59258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}